Opportunity Information: Apply for PA 18 699
The grant opportunity titled "Basic and Translational Oral Health Research Related to HIV/AIDS (R01 Clinical Trial Not Allowed)" (Funding Opportunity Number PA-18-699) is a discretionary NIH research grant aimed at advancing basic and translational science on how HIV affects the oral cavity. The main focus is on innovative studies that clarify the mechanisms involved in HIV transmission through oral tissues, viral persistence in oral reservoirs, disease pathogenesis in the mouth, and oral HIV-related co-morbidities. In practical terms, the FOA is looking for lab-based and translational projects that can explain why oral tissues may contribute to infection risk, how HIV survives or hides in oral environments, how HIV and immune responses interact locally in the mouth, and how oral health complications connect with HIV infection and its treatment. As an R01 mechanism, it is designed for substantial, hypothesis-driven research programs rather than small pilot efforts, and the "Clinical Trial Not Allowed" designation means applicants should not propose clinical trials; the emphasis is on basic and translational research rather than testing interventions in trial formats.
The opportunity is administered by the National Institutes of Health under CFDA 93.121, which is associated with oral health research (commonly tied to NIH dental and craniofacial research programs). Projects supported under this FOA would typically include mechanistic work in relevant experimental systems, such as cellular and molecular studies of oral mucosal immunity, host-pathogen interactions, the oral microbiome and mycobiome in the context of HIV, inflammation pathways that influence oral disease, and biological links between HIV and oral conditions that may complicate overall health. Translational elements are encouraged when they are built on solid biological rationale, for example using human oral tissue samples, clinically relevant models, or biomarker-oriented approaches, as long as the work remains outside the definition of a clinical trial.
Eligibility is broad and intentionally inclusive. In addition to standard applicant types like state, county, and local governments; public and state-controlled universities; private institutions of higher education; and independent school districts, the FOA permits applications from a wide range of organizational structures. Eligible applicants include federally recognized Native American tribal governments and tribal organizations (including those other than federally recognized tribal governments), public housing authorities/Indian housing authorities, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses. The FOA also explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, and non-U.S. entities (foreign organizations) as well as regional organizations. This signals an interest in attracting applications from diverse institutional settings and geographic contexts, including international partners when scientifically justified.
Key administrative details from the source information include that the opportunity was created on March 5, 2018, and listed an original closing date of January 7, 2021. The funding instrument is a grant and the activity category is health. The award ceiling and expected number of awards are not specified in the provided data, which often means budgets and award counts depend on NIH institute priorities, application volume, scientific merit, and available appropriations in a given cycle. Overall, this FOA is best understood as an NIH R01 invitation for rigorous mechanistic and translational oral-health-focused HIV/AIDS research, with a clear boundary excluding clinical trial proposals and an applicant pool that includes academic, governmental, nonprofit, community-based, for-profit, tribal, territorial, and foreign organizations.Apply for PA 18 699
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Basic and Translational Oral Health Research Related to HIV/AIDS (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
- This funding opportunity was created on 2018-03-05.
- Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Basic and Translational Oral Health Research Related to HIV/AIDS (R01 Clinical Trial Not Allowed) - PA-18-699
1) What is the title and funding opportunity number for this grant?
The opportunity is titled "Basic and Translational Oral Health Research Related to HIV/AIDS (R01 Clinical Trial Not Allowed)" and the Funding Opportunity Number (FOA) is PA-18-699.
2) What kind of grant mechanism is this?
This is an NIH R01 discretionary research grant. The R01 mechanism is generally intended for substantial, hypothesis-driven research programs rather than small pilot or exploratory efforts.
3) What is the overall purpose of this FOA?
The purpose is to advance basic and translational science on how HIV affects the oral cavity. The FOA emphasizes innovative research that clarifies biological mechanisms related to HIV in oral tissues and oral health conditions linked to HIV/AIDS.
4) What research topics and scientific questions are a good fit?
Projects that fit well are those focused on mechanisms, including topics such as:
- How HIV transmission may involve oral tissues or oral biological processes
- How HIV persists in oral reservoirs and what enables viral persistence in oral environments
- Oral disease pathogenesis related to HIV infection in the mouth
- Oral HIV-related co-morbidities and how they connect to HIV infection and/or treatment
- Local interactions between HIV and oral immune responses
- Host-pathogen interactions in oral tissues in the context of HIV
- Oral mucosal immunity (cellular and molecular mechanisms)
- Roles of the oral microbiome and mycobiome in the context of HIV
- Inflammation pathways that influence oral disease in the setting of HIV
- Biological links between HIV and oral conditions that may complicate overall health
5) Is this FOA looking for basic research, translational research, or both?
Both. The FOA is aimed at basic and translational oral health research related to HIV/AIDS. Translational elements are encouraged when grounded in strong biological rationale and when they remain outside the definition of a clinical trial.
6) What does "Clinical Trial Not Allowed" mean for applicants?
Applicants should not propose clinical trials under this FOA. The emphasis is on basic and translational research rather than testing interventions in a clinical trial format.
7) Are human samples or clinically relevant materials allowed if clinical trials are not?
Yes, translational elements are encouraged when scientifically justified. Examples mentioned include using human oral tissue samples, clinically relevant models, or biomarker-oriented approaches, as long as the project does not meet the definition of a clinical trial.
8) What types of research approaches are implied as appropriate for this FOA?
The FOA points toward mechanistic work in relevant experimental systems, including cellular and molecular studies of oral mucosal immunity, host-pathogen interactions, studies involving the oral microbiome and mycobiome in HIV contexts, inflammation pathway research related to oral disease, and mechanistic studies linking HIV to oral co-morbidities.
9) Which agency administers this opportunity?
The opportunity is administered by the National Institutes of Health (NIH).
10) What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.121, which is associated with oral health research and is commonly tied to NIH dental and craniofacial research programs.
11) What is the funding instrument and activity category?
The funding instrument is a grant, and the activity category is health.
12) Who is eligible to apply?
Eligibility is broad and includes many organization types, such as:
- State, county, and local governments
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Independent school districts
- Federally recognized Native American tribal governments
- Native American tribal organizations (including those other than federally recognized tribal governments)
- Public housing authorities/Indian housing authorities
- Nonprofit organizations (with or without 501(c)(3) status)
- For-profit organizations (other than small businesses)
- Small businesses
- Eligible federal agencies
- U.S. territories or possessions
- Non-U.S. entities (foreign organizations)
- Regional organizations
13) Does the FOA encourage applications from specific institution types?
Yes. The FOA explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving Institutions, HBCUs, TCCUs, and faith-based or community-based organizations.
14) Are foreign organizations allowed to apply?
Yes. The FOA includes non-U.S. entities (foreign organizations) and regional organizations among eligible applicants, indicating that international participation is allowed when scientifically justified.
15) Is this opportunity intended for small pilot projects?
No. As an R01 mechanism, it is described as designed for substantial, hypothesis-driven research programs rather than small pilot efforts.
16) What kinds of oral HIV/AIDS outcomes or problem areas is the FOA trying to understand?
The FOA is centered on explaining mechanisms behind oral tissue involvement in infection risk, viral persistence in oral reservoirs, local HIV-immune interactions in the mouth, oral disease pathogenesis, and oral co-morbidities related to HIV infection and treatment.
17) When was this opportunity created?
The source information indicates the opportunity was created on March 5, 2018.
18) What is the (original) closing date listed for this FOA?
The information provided lists an original closing date of January 7, 2021.
19) How many awards will be made and what is the maximum award amount?
The award ceiling and expected number of awards are not specified in the provided information. This often means budgets and award counts may depend on NIH institute priorities, application volume, scientific merit, and available appropriations in a given cycle.
20) How should applicants interpret the emphasis on "innovative studies" in this FOA?
Based on the description provided, "innovative studies" refers to research that can clarify underlying mechanisms in oral HIV biology (for example, why oral tissues may contribute to infection risk, how HIV persists in oral environments, and how oral co-morbidities arise), using rigorous basic and translational approaches rather than clinical trial designs.
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