Basic and Translational Oral Health Research Related to HIV/AIDS (R01 Clinical Trial Not Allowed) | PA 18 699

Opportunity Information: Apply for PA 18 699

The grant opportunity titled "Basic and Translational Oral Health Research Related to HIV/AIDS (R01 Clinical Trial Not Allowed)" (Funding Opportunity Number PA-18-699) is a discretionary NIH research grant aimed at advancing basic and translational science on how HIV affects the oral cavity. The main focus is on innovative studies that clarify the mechanisms involved in HIV transmission through oral tissues, viral persistence in oral reservoirs, disease pathogenesis in the mouth, and oral HIV-related co-morbidities. In practical terms, the FOA is looking for lab-based and translational projects that can explain why oral tissues may contribute to infection risk, how HIV survives or hides in oral environments, how HIV and immune responses interact locally in the mouth, and how oral health complications connect with HIV infection and its treatment. As an R01 mechanism, it is designed for substantial, hypothesis-driven research programs rather than small pilot efforts, and the "Clinical Trial Not Allowed" designation means applicants should not propose clinical trials; the emphasis is on basic and translational research rather than testing interventions in trial formats.

The opportunity is administered by the National Institutes of Health under CFDA 93.121, which is associated with oral health research (commonly tied to NIH dental and craniofacial research programs). Projects supported under this FOA would typically include mechanistic work in relevant experimental systems, such as cellular and molecular studies of oral mucosal immunity, host-pathogen interactions, the oral microbiome and mycobiome in the context of HIV, inflammation pathways that influence oral disease, and biological links between HIV and oral conditions that may complicate overall health. Translational elements are encouraged when they are built on solid biological rationale, for example using human oral tissue samples, clinically relevant models, or biomarker-oriented approaches, as long as the work remains outside the definition of a clinical trial.

Eligibility is broad and intentionally inclusive. In addition to standard applicant types like state, county, and local governments; public and state-controlled universities; private institutions of higher education; and independent school districts, the FOA permits applications from a wide range of organizational structures. Eligible applicants include federally recognized Native American tribal governments and tribal organizations (including those other than federally recognized tribal governments), public housing authorities/Indian housing authorities, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses. The FOA also explicitly highlights additional eligible applicant categories, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, and non-U.S. entities (foreign organizations) as well as regional organizations. This signals an interest in attracting applications from diverse institutional settings and geographic contexts, including international partners when scientifically justified.

Key administrative details from the source information include that the opportunity was created on March 5, 2018, and listed an original closing date of January 7, 2021. The funding instrument is a grant and the activity category is health. The award ceiling and expected number of awards are not specified in the provided data, which often means budgets and award counts depend on NIH institute priorities, application volume, scientific merit, and available appropriations in a given cycle. Overall, this FOA is best understood as an NIH R01 invitation for rigorous mechanistic and translational oral-health-focused HIV/AIDS research, with a clear boundary excluding clinical trial proposals and an applicant pool that includes academic, governmental, nonprofit, community-based, for-profit, tribal, territorial, and foreign organizations.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Basic and Translational Oral Health Research Related to HIV/AIDS (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
• This funding opportunity was created on 2018-03-05.
• Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 18 699

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