Opportunity Information: Apply for PAR 18 681
The National Institutes of Health (NIH) funding opportunity PAR-18-681, titled "Fundamental Mechanisms of Affective and Decisional Processes in Cancer Control (R01 Clinical Trial Optional)," supports R01 research projects aimed at building foundational, mechanistic knowledge about how affective processes (for example, emotions, feelings, stress responses, worry, anticipated regret, fear, or affect-laden perceptions of risk) shape decisions and behaviors that matter for cancer prevention and cancer control. The emphasis is on basic affective science that can explain why people make certain cancer-related choices, and how those choices unfold over time, in ways that can ultimately inform better strategies across the cancer control continuum.
A central theme of the FOA is understanding affect as a driver of both single-event decisions and repeated or ongoing decision patterns. Single-event decisions might include choosing whether to get screened for cancer, follow up after an abnormal test, vaccinate (when applicable), or pursue genetic counseling or testing. Multi-event decisions and behaviors include recurring or sustained actions like adhering to an oral chemotherapy regimen, sticking with survivorship care plans, maintaining lifestyle changes relevant to risk reduction, attending repeated appointments, or continuing symptom monitoring and reporting. By calling out both one-time and repeated decisions, the opportunity highlights the reality that cancer-related behavior is often not a single choice but a series of linked decisions influenced by shifting emotional states and contexts.
The FOA also aims to bring together cancer control researchers with investigators from disciplines not traditionally tied to cancer control applications, specifically naming areas such as affective and cognitive neuroscience, decision science, and consumer science. The goal of these cross-disciplinary collaborations is to tackle persistent and understudied puzzles in affective and decision sciences that have downstream implications for cancer prevention and control. In practice, this could include research that clarifies mechanisms like how emotional responses interact with cognition and attention, how people weigh immediate emotional costs against long-term health benefits, how affect influences information seeking or avoidance, or how context (clinical settings, family dynamics, media exposure, financial stress) shapes emotional processing and ultimately health choices.
From an applicant and project design standpoint, this is a discretionary NIH grant using the R01 mechanism, with clinical trials allowed but not required (clinical trial optional). That means applicants can propose purely basic/mechanistic studies, observational or experimental behavioral research, or clinical trial components when appropriate, as long as the work is aligned with generating fundamental knowledge about affective and decisional processes that matter to cancer control outcomes. The activity category is listed under education and health, and the CFDA number associated with the opportunity is 93.393.
Eligibility is broad and includes many types of U.S.-based organizations and government entities, such as state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (outside institutions of higher education); for-profit organizations other than small businesses; and small businesses. The announcement also explicitly calls out additional eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This breadth signals an intent to encourage wide participation, including organizations that serve populations disproportionately affected by cancer burden and disparities.
Key administrative details included in the source data are the opportunity number (PAR-18-681), the creation date (2018-02-27), and an original closing date listed as 2019-10-11. The award ceiling and expected number of awards are not specified in the provided data. Overall, the opportunity is best read as NIH investing in the underlying science of emotion and decision-making as it relates to cancer-related choices, with the expectation that stronger mechanistic insight will eventually translate into more effective cancer prevention and control strategies, interventions, and communication approaches.Apply for PAR 18 681
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Fundamental Mechanisms of Affective and Decisional Processes in Cancer Control (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393.
- This funding opportunity was created on 2018-02-27.
- Applicants must submit their applications by 2019-10-11. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the funding opportunity PAR-18-681?
PAR-18-681 is a National Institutes of Health (NIH) funding opportunity titled "Fundamental Mechanisms of Affective and Decisional Processes in Cancer Control (R01 Clinical Trial Optional)." It supports R01 research projects focused on building foundational, mechanistic knowledge about how affective processes shape cancer-related decisions and behaviors.
What is the main goal of this FOA?
The main goal is to advance basic, mechanistic understanding of how affect (such as emotions, stress responses, worry, fear, anticipated regret, or affect-laden risk perceptions) influences decisions and behaviors across cancer prevention and cancer control, in ways that can ultimately inform better strategies across the cancer control continuum.
What types of affective processes are in scope?
The FOA highlights affective processes including emotions and feelings, stress responses, worry, anticipated regret, fear, and affect-laden perceptions of risk, among other emotional and affect-related drivers that can shape health decisions and behaviors relevant to cancer control.
What kinds of cancer-related decisions does the FOA emphasize?
The FOA emphasizes both single-event decisions and multi-event (repeated or ongoing) decision patterns that matter for cancer prevention and control.
What are examples of single-event decisions relevant to this opportunity?
Examples include deciding whether to get screened for cancer, whether to follow up after an abnormal test result, whether to vaccinate (when applicable), and whether to pursue genetic counseling or genetic testing.
What are examples of multi-event or ongoing behaviors relevant to this opportunity?
Examples include adhering to an oral chemotherapy regimen, following survivorship care plans, maintaining lifestyle changes for risk reduction, attending repeated clinical appointments, and continuing symptom monitoring and reporting over time.
Why does the FOA distinguish between one-time and repeated decisions?
Because many cancer-related behaviors are not a single isolated choice, but a series of linked decisions that unfold over time and can be influenced by changing emotional states and shifting contexts.
What is meant by "fundamental" or "mechanistic" knowledge in this FOA?
It refers to research aimed at explaining the underlying processes and pathways through which affect influences cognition, attention, information seeking or avoidance, and decision-making over time, rather than focusing only on applied outcomes. The intent is to generate basic affective science insights that can later inform strategies in cancer prevention and control.
Is this FOA focused on applied interventions or basic science?
The emphasis is on basic affective science and mechanistic understanding of affective and decisional processes. The FOA frames this foundational work as something that can ultimately inform better strategies and approaches across the cancer control continuum.
What research disciplines does the FOA encourage applicants to bring together?
The FOA aims to bring together cancer control researchers with investigators from disciplines not traditionally tied to cancer control applications, specifically naming areas such as affective and cognitive neuroscience, decision science, and consumer science.
What is the purpose of encouraging cross-disciplinary collaborations?
The purpose is to address persistent and understudied puzzles in affective and decision sciences that have downstream implications for cancer prevention and control, by combining perspectives and methods from multiple fields.
What kinds of mechanisms or questions might fit this FOA (based on the description)?
Examples mentioned include: how emotional responses interact with cognition and attention; how people weigh immediate emotional costs against long-term health benefits; how affect influences information seeking or information avoidance; and how context (clinical settings, family dynamics, media exposure, financial stress) shapes emotional processing and health choices.
What grant mechanism does PAR-18-681 use?
This is an NIH discretionary grant using the R01 mechanism.
Are clinical trials required under this FOA?
No. The FOA is "Clinical Trial Optional," meaning clinical trials are allowed but not required.
What kinds of study designs are allowed under "clinical trial optional" (as described)?
Applicants may propose purely basic/mechanistic studies, observational or experimental behavioral research, or clinical trial components when appropriate, as long as the work aligns with generating fundamental knowledge about affective and decisional processes relevant to cancer control outcomes.
What topic area or activity category is associated with the opportunity?
The activity category is listed under education and health.
What CFDA number is associated with this opportunity?
The CFDA number associated with the opportunity is 93.393.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S.-based organizations and government entities, as well as non-U.S. entities (foreign organizations) as explicitly stated in the opportunity description.
What types of U.S. government entities are eligible?
Eligible entities include state governments, county governments, local governments, special district governments, independent school districts, and eligible federal agencies.
Are higher education institutions eligible?
Yes. Eligible organizations include public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes federally recognized Native American tribal governments and tribal organizations that are not federally recognized.
Are nonprofits eligible, including those without 501(c)(3) status?
Yes. Eligibility includes nonprofits with or without 501(c)(3) status (outside institutions of higher education).
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations other than small businesses, and it also includes small businesses.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are included in the eligibility list.
Are faith-based or community-based organizations eligible?
Yes. The announcement explicitly calls out faith-based or community-based organizations as eligible applicants.
Are minority-serving institutions specifically named as eligible?
Yes. The eligibility list explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are regional organizations and U.S. territories eligible?
Yes. The eligibility list includes regional organizations and U.S. territories or possessions.
Are non-U.S. entities eligible to apply?
Yes. The announcement explicitly includes non-U.S. entities (foreign organizations) among eligible applicants.
What is the opportunity number for this FOA?
The opportunity number is PAR-18-681.
What is the creation date listed for this opportunity?
The creation date listed in the provided information is 2018-02-27.
What is the original closing date listed for this opportunity?
The original closing date listed in the provided information is 2019-10-11.
Is the award ceiling provided?
No. The award ceiling is not specified in the provided data.
Is the expected number of awards provided?
No. The expected number of awards is not specified in the provided data.
How does this FOA connect affective science to cancer control impact?
It positions affect as a key driver of cancer-relevant choices (both one-time and repeated decisions), and seeks foundational understanding of these processes so that the resulting mechanistic insights can ultimately support more effective cancer prevention and control strategies, interventions, and communication approaches.
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| Research Answers to National Cancer Institute's (NCI) Provocative Questions (R01 Clinical Trial Optional) Apply for RFA CA 18 019 Funding Number: RFA CA 18 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Research Answers to National Cancer Institute's (NCI) Provocative Questions (R21 Clinical Trial Optional) Apply for RFA CA 18 020 Funding Number: RFA CA 18 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Advancing Exceptional Research on HIV/AIDS and Substance Abuse (R01, Clinical Trial Optional) Apply for RFA DA 18 022 Funding Number: RFA DA 18 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Coordinating Center to Support NIDA Rural Opioid HIV and Comorbidity Initiative (U24 - Clinical Trial Not Allowed) Apply for RFA DA 19 004 Funding Number: RFA DA 19 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Fogarty HIV Research Training Program for Low-and Middle-Income Country Institutions (D43 Clinical Trial Optional) Apply for PAR 18 717 Funding Number: PAR 18 717 Agency: National Institutes of Health Category: Education, Health Funding Amount: $280,000 |
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| Exploratory Grant Award to Promote Workforce Diversity in Basic Cancer Research (R21 Clinical Trial Not Allowed) Apply for PAR 18 731 Funding Number: PAR 18 731 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Age-related Microbiota Changes and their Implications in Chronic Disease Prevention, Treatment and Progression (R01 Clinical Trial Optional). Apply for PA 18 738 Funding Number: PA 18 738 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Age-related Microbiota Changes and their Implications in Chronic Disease Prevention, Treatment and Progression (R21 Clinical Trial Optional). Apply for PA 18 739 Funding Number: PA 18 739 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Revision Applications to National Cancer Institute (NCI)-supported P50 Awards to Include Research on the NCIs Provocative Questions (P50 Clinical Trial Optional) Apply for RFA CA 18 024 Funding Number: RFA CA 18 024 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to National Cancer Institute (NCI) supported U01 Awards to Include Research on the NCIs Provocative Questions (U01 Clinical Trial Optional) Apply for RFA CA 18 022 Funding Number: RFA CA 18 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to National Cancer Institute (NCI) Supported R01 Awards to Include Research on the NCIs Provocative Questions (R01 Clinical Trial Optional) Apply for RFA CA 18 021 Funding Number: RFA CA 18 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Exploring Epigenomic or Non-Coding RNA Regulation in the Development, Maintenance, or Treatment of Chronic Pain (R61/R33 Clinical Trial Optional) Apply for PAR 18 742 Funding Number: PAR 18 742 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications to National Cancer Institute (NCI)-supported P01 Awards to Include Research on the NCIs Provocative Questions (P01 Clinical Trial Optional) Apply for RFA CA 18 023 Funding Number: RFA CA 18 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
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