Opportunity Information: Apply for CDC RFA GH 23 0035
This funding opportunity, CDC RFA GH 23 0035, is a PEPFAR-supported cooperative agreement focused on strengthening laboratory systems in the Republic of South Sudan so the country can deliver reliable, high-quality laboratory services that underpin HIV/AIDS diagnosis, treatment monitoring, and surveillance. The program is designed to build the Ministry of Health's capacity to manage and sustain these services nationally, rather than relying on fragmented or temporary support. While the listed Year 1 award ceiling is shown as 0 (meaning no fixed cap was set in the notice), CDC indicated an expected total funding amount of about USD 5,000,000 for the first year, contingent on available funds, and anticipated making one award.
The core technical emphasis is improving access to and performance of priority HIV laboratory services that directly affect patient outcomes and program impact. The recipient is expected to expand viral load testing services so that more people on antiretroviral treatment can be monitored appropriately, with the goal of improving coverage of viral load testing and ultimately increasing viral suppression. The opportunity also prioritizes expanding Early Infant Diagnosis services, with a specific push to improve testing coverage for infants under two months of age, since delays in infant testing and results can lead to missed or late treatment initiation. In addition, the program aims to raise the quality of HIV rapid testing across the country, ensuring testing is accurate and consistent, and to strengthen monitoring of HIV drug resistance, which supports more effective treatment strategies and helps the national program detect emerging resistance patterns early.
Beyond individual tests, the grant is framed around system-level improvements that make laboratory services dependable, standardized, and sustainable. A major component involves supporting selected laboratories to pursue international accreditation, paired with continuous quality improvement activities so that quality gains are maintained over time and embedded in routine operations. The opportunity also calls for establishing a sustainable electronic laboratory information management system (LIMS), which is meant to improve tracking of specimens, results reporting, data quality, and the ability to use laboratory data for clinical and public health decision-making. Another key deliverable is sustaining a functional national sample transportation system, recognizing that reliable specimen referral networks are essential in settings where many patients receive care far from central testing sites.
The notice further emphasizes strengthening the enabling environment for laboratories, not just the technical bench work. This includes establishing a laboratory professional regulatory council to support professional standards and oversight, improving laboratory supply systems to reduce stockouts and ensure consistent availability of reagents and consumables, and supporting the development or updating of national laboratory policies, guidelines, and strategic plans. Taken together, these activities are intended to help South Sudan build a coherent national laboratory system that can support HIV service delivery end-to-end, from testing and diagnosis through ongoing treatment monitoring and surveillance.
Finally, because this is described as the only PEPFAR laboratory system strengthening program in South Sudan, it is positioned as a central pillar for broader public health readiness. While the immediate focus is HIV, the strengthened infrastructure, quality systems, data systems, specimen transport, and workforce regulation are also expected to improve the country's capacity for earlier detection of other diseases of public health significance, making the laboratory network more resilient and more useful for outbreak detection and response. The opportunity was open to unrestricted applicants, was issued by the U.S. Department of Health and Human Services through CDC's Center for Global Health, and had an original application due date of March 13, 2023, with electronic submissions due by 11:59 pm Eastern Time.Apply for CDC RFA GH 23 0035
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Strengthening Laboratory Systems that Support Diagnosis, Treatment, Prevention, and Management of HIV/AIDS and Related Public Health Diseases in the Republic of South Sudan under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Jan 12, 2023.
- Applicants must submit their applications by Mar 13, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is the grant opportunity being offered?
This opportunity is CDC RFA GH 23 0035, a PEPFAR-supported cooperative agreement focused on strengthening laboratory systems in the Republic of South Sudan to deliver reliable, high-quality laboratory services that support HIV/AIDS diagnosis, treatment monitoring, and surveillance.
Who is funding and issuing this opportunity?
The opportunity was issued by the U.S. Department of Health and Human Services (HHS) through the Centers for Disease Control and Prevention (CDC), specifically CDC's Center for Global Health, and it is supported by PEPFAR.
Where will the program activities take place?
The work is focused on the Republic of South Sudan, with the goal of strengthening laboratory services nationally.
What is the main purpose of the program?
The program aims to strengthen South Sudan's national laboratory system so the country can manage and sustain dependable, standardized laboratory services over time, reducing reliance on fragmented or temporary support and improving the laboratory foundation for HIV program delivery.
Is the focus only on HIV, or does it support other public health needs too?
The immediate focus is HIV laboratory services and systems. However, the notice indicates that strengthening infrastructure, quality systems, data systems, specimen transport, and workforce regulation is also expected to improve capacity for earlier detection of other diseases of public health significance and strengthen outbreak detection and response readiness.
What types of HIV laboratory services are prioritized?
The opportunity emphasizes improving access to and performance of priority HIV laboratory services that directly affect patient outcomes and program impact, including viral load testing, Early Infant Diagnosis (EID), HIV rapid testing quality, and HIV drug resistance monitoring.
What does the grant expect regarding viral load testing?
The recipient is expected to expand viral load testing services so more people on antiretroviral treatment can be monitored appropriately. The stated intent is to improve viral load testing coverage and ultimately increase viral suppression.
What does the grant prioritize for Early Infant Diagnosis (EID)?
The program prioritizes expanding EID services, with a specific push to improve testing coverage for infants under two months of age. This emphasis is tied to reducing delays in infant testing and results that can lead to missed or late treatment initiation.
How does the opportunity address HIV rapid testing?
It aims to raise the quality of HIV rapid testing across South Sudan so testing is accurate and consistent.
What does "strengthening monitoring of HIV drug resistance" mean in this opportunity?
The grant prioritizes strengthening HIV drug resistance monitoring to support more effective treatment strategies and help the national program detect emerging resistance patterns early.
What system-level improvements are expected beyond individual tests?
The opportunity is framed around making laboratory services dependable, standardized, and sustainable. It includes accreditation-focused quality improvements, implementation of an electronic laboratory information management system (LIMS), and sustaining a national sample transportation system, along with broader policy, regulatory, and supply system strengthening.
Does the opportunity include laboratory accreditation activities?
Yes. A major component is supporting selected laboratories to pursue international accreditation, paired with continuous quality improvement activities so quality gains are maintained over time and embedded in routine operations.
What is the role of continuous quality improvement in this program?
Continuous quality improvement is described as a companion to accreditation efforts, intended to help sustain quality gains over time and integrate quality practices into routine laboratory operations.
Is a Laboratory Information Management System (LIMS) required?
The opportunity calls for establishing a sustainable electronic LIMS to improve specimen tracking, results reporting, data quality, and the use of laboratory data for clinical and public health decision-making.
Why does the opportunity emphasize a sample transportation system?
It identifies sustaining a functional national sample transportation system as a key deliverable, recognizing that reliable specimen referral networks are essential in settings where many patients receive care far from central testing sites.
What does the opportunity say about strengthening the "enabling environment" for laboratories?
It emphasizes strengthening more than technical bench work by improving the systems that support laboratories. This includes establishing a professional regulatory council, improving supply systems, and supporting national policies, guidelines, and strategic plans.
What is the laboratory professional regulatory council mentioned in the notice?
The notice calls for establishing a laboratory professional regulatory council to support professional standards and oversight for the laboratory workforce.
How are laboratory supplies addressed in this opportunity?
The program includes improving laboratory supply systems to reduce stockouts and ensure consistent availability of reagents and consumables.
Does the opportunity include work on national laboratory policies and planning?
Yes. It supports the development or updating of national laboratory policies, guidelines, and strategic plans to help build a coherent national laboratory system.
How many awards did CDC anticipate making?
CDC anticipated making one award.
How much funding was expected for the first year?
CDC indicated an expected total funding amount of about USD 5,000,000 for the first year, contingent on available funds.
Why does the Year 1 award ceiling show as 0?
The notice lists the Year 1 award ceiling as 0 to indicate that no fixed cap was set in the notice, while CDC separately indicated an expected first-year total funding amount of about USD 5,000,000 (contingent on available funds).
Is this described as a central laboratory strengthening effort in South Sudan?
Yes. The notice states this is the only PEPFAR laboratory system strengthening program in South Sudan, positioning it as a central pillar for laboratory system strengthening with broader public health readiness benefits.
Who was eligible to apply?
The opportunity was open to unrestricted applicants, according to the notice.
What type of funding mechanism is this?
It is described as a cooperative agreement.
When was the application due?
The original application due date was March 13, 2023.
What was the submission method and deadline time zone?
Submissions were electronic, due by 11:59 pm Eastern Time on the due date.
What is the overall intended outcome for South Sudan's Ministry of Health?
The program is designed to build the Ministry of Health's capacity to manage and sustain reliable, high-quality laboratory services nationally, embedding standardized systems and long-term functionality rather than short-term or fragmented support.
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